Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 86-92
EXPERIMENTAL DATA REGARDING THE EFFECTS OF AMIODARONE IN PREGNANT RATS
Razvan GLIGOR1, Virginia GLIGOR2
1UMF, Timisoara, Romania
2University of “V. Goldis”, Arad, Romania
Streszczenie
The present study was designed to evaluate the effects of amiodarone, an antianginal and antiarrhythmic agent on pregnant rats. The drug was administered at dosages of 10 mg/kg/day and 90 mg/kg/day, intaperitoneally, once, to the pregnant female rats (on the 10th and the 12th day of gestation). Clinical signs, body weight and feed consumption were recorded daily. Evaluations were made for number of newborn cubs and number of cubs born dead, number of cubs born with malformations and number of cubs dead after birth (during the first 30 days); cubs were also examined for body weight. An increased frequency of deaths amongst newborn cubs and a decrease in their body weights were observed in rats to which doses of 90 mg/kg/day were administered. In the same way, it has been shown that the offspring nursing by lactating rats, treated during gestation with amiodarone, were less viable and have gained reduced body-weight.
Słowa kluczowe
Amiodarone; Embriogenesis; Malformations.