Problems of Forensic Sciences 2005 Vol. 63 (LXIII) 241-246
SCREENING ANALYSIS OF FOURTEEN CLASSIC PSYCHOTROPIC DRUGS BY THE NON-AQUEOUS CAPILLARY ELECTROPHORESIS METHOD
Katarzyna MADEJ, Anna MARCZYK, Michał WOŹNIAKIEWICZ
Faculty of Chemistry, Jagiellonian University, Cracow
Streszczenie
In our examinations, sixteen psychotropic drugs from the phenothiazines and tricyclic antidepressants group were studied. For the purpose of screening analysis, the separation conditions of the drugs were studied using capillary electrophoresis in a non-aqueous medium. The influence of both background electrolyte composition and the kind of medium used for dissolution of the drugs on the separation efficiency was examined. Noxiptyline was selected as the internal standard. In optimal separation conditions, the identification parameter – relative migration time (RMT) – and repeatability of the identification parameter for each drug tested were determined.
Słowa kluczowe
Phenothiazines; Tricyclic antidepressants; Screening analysis, Non-aqueous capillary electrophoresis.