Problems of Forensic Sciences 2003 Vol. 55 (LV) 37-49
A STUDY OF HYDROGEN PEROXIDE CONCENTRATION CHANGES IN ORGANS OF RATS PROTRACTEDLY INTOXICATED WITH ETHANOL, METANOL, AND ETHYLENE GLYCOL
Agnieszka P. JURCZYK, Maciej BARZDO, Ewa MEISSNER, Beata JANKOWSKA, Jarosław BERENT, Krzysztof KORDEL, Stefan SZRAM
Chair and Department of Forensic Medicine, Medical University, Łódź
Streszczenie
The results of research carried out on rats, assessing the influence of chronic intoxication with ethanol, methanol, and ethylene glycol on hydrogen peroxide concentration in internal organs – brain, lungs, liver, kidney, and heart – are presented in this paper. It was shown that the organ most exposed to the detrimental activity of ethanol, methanol, and ethylene glycol is the heart: the greatest increase in hydrogen peroxide concentration was ascertained in this organ. The highest rise in the hydrogen peroxide concentration in all the organs (with the exception of brain) was noted in the case of intoxication with ethylene glycol. Ethanol revealed its antioxidant properties in the brain and kidneys, causing a decrease of the hydrogen peroxide concentration. The lungs turned out to be the only organ in which an increase in hydrogen peroxide concentration occurred during chronic intoxication with all the examined alcohols – ethanol, methanol, and ethylene glycol.
Słowa kluczowe
Oxidative stress; Hydrogen peroxide; Ethanol; Methanol; Ethylene glycol.