Problems of Forensic Sciences 2002 Vol. 49 (XLIX) 114-127
DIGOXIN IN A FORENSIC LABORATORY – AN ANALYSIS OF CASES
Piotr ADAMOWICZ, Ewa CHUDZIKIEWICZ, Maria KAŁA
Institute of Forensic Research, Cracow
Streszczenie
In this work, methods of determination of digoxin and methyldigoxin in biological (blood, urine and liver) and non-biological material (tablets) have been presented on the basis of two cases of poisoning as examples. It has been shown that in the course of systematic toxicological analysis carried out using TLC, GC/MS and HPLC methods, digoxin and its analogues can be missed, even in cases where they are present in high concentrations. Detection of digoxin and its analogues in post-mortem material requires application of a targeted analysis after obtaining a preliminary positive result with immunoenzymatic methods. Identification of digoxin in tablets causes great difficulties due to its low concentrations and weakly characteristic analytical signals obtained with the use of instrumental methods.
Słowa kluczowe
Digoxin and its analogues; Screening and immunoenzymatic methods; Biological and non-biological materials.