Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 131-136
CAPILLARY ELECTROPHORETIC ENANTHIOMER SEPARATION OF AMPHETAMINES AFTER THE ADMINISTRATION OF L-DEPRENYL TO MAN
Eunmi KIM1, Sunchun KIM1, Meejung PARK1, Heesun CHUNG1, Youngchan YOO1, Kongju LEE2, Hwajung KIM2
1National Institute of Scientific Investigation, Seoul, Korea
2College of Pharmacy, Ewha Women’s University, Seoul, Korea
Streszczenie
The enantiomeric analysis in urine collected from volunteers ingested with l-deprenyl by capillary electrophoresis (CE) using carboxy methylated-β-cyclodextrin (CMCD) as a chiral selector was investigated to compare the metabolic pattern of l-deprenyl with the metabolism of d-MA. l-Deprenyl and its metabolites, l-MA, l-AM and l-DMS were detected in human urine sample. The AM/MA ratio from l-deprenyl user (0.33 ± 0.03) was significantly higher than the ratio from MA abusers (0.20 ± 0.12).
Słowa kluczowe
Enantiomeric separation; Capillary electrophoresis; Deprenyl; Methamphetamine; Amphetamine.