Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 200-207
EVALUATION OF SAMPLE PREPARATION TECHNIQUES ADEQUATE FOR MULTIVARIATE ALGORITHMS APPLIED FOR THE IDENTIFICATION AND CLASSIFICATION OF AMPHETAMINE ANALOGUES WITH GC-FTIR
Mirela PRAISLER, Inge DIRINCK,Willy LAMBERT, Andreas DE LEENHEER, Luc MASSART
Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, University of Ghent, Ghent, Belgium
Streszczenie
Sample preparation techniques were evaluated for street samples as part of an optimization strategy in forming the GC-FTIR knowledge base of an expert system based on Soft Independent Modelling of Class Analogy (SIMCA). The spectra of the nonderivatized amphetamines have larger discrimination power than those of their HFB-derivatives. Significant changes in band profiles are more valuable information for the knowledge base of the expert system, than an increased number of common absorption bands with profiles less sensitive to small molecular structural changes.
Słowa kluczowe
Amphetamines; FTIR spectra; Soft independent modelling of class analogy (SIMCA).