Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 11-17
PARAOXONASE AND ACETYLCHOLINESTERASE ACTIVITIES IN HUMANS EXPOSED TO ORGANOPHOSPHOROUS COMPOUNDS
Serap A. AKGÜR1, Pembe ÖZTÜRK1, Eser Y. SÖZMEN2, Yasemin DELEN2, Tijen TANYALÇIN2, Beyhan EGE1
1Departament of Forensic Medicine, Ege University, Izmir, Turkey
2Departament of Biochemistry, Ege University, Izmir, Turkey
Streszczenie
Organophoshorous compounds (OP) are used as pesticides in Turkish agriculture. OP inhibit acetylcholinesterase (AchE) activities on the other hand serum paraoxonase (PON1) hydrolyzes the toxic metabolites of a variety of OP. AChE and PON1 activities in serum were measured spectrophotometrically. The individuals were classified for PON1 phenotypes as A, AB and B types. A positive correlation was found between AChE activities and percent of PON1 stimulation. This study suggests that individuals with phenotypeAmight be more sensitive to OP induced toxicity.
Słowa kluczowe
Paraxonase; Acetylcholinesterase; Organophosphorous compounds.