Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 137-143
SIMULTANEOUS DETERMINATION OF TRIAZOLAM AND ITS METABOLITES IN HUMAN BLOOD AND URINE BY GC/MS
Keiko KUDO, Noriaki IKEDA, Yukiko HINO
Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Streszczenie
A sensitive and selective method has been developed for simultaneous determination of triazolam and its major metabolites, α-hydroxytriazolam and 4-hydroxytriazolam in human whole blood and urine. The drugs were effectively extracted using a 3-step solvent extraction procedure followed by tert-butyldimethylsilyl derivatization, and subjected to GC/MS in the negative ion chemical ionization mode.
Słowa kluczowe
Triazolam; Hydroxytriazolam; GC/MS.