Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 192-199
ANALYSIS OF MECONIUM FOR AMPHETAMINES AND OPIATES. OUR FIRST EXPERIMENT
Eva NOVÁKOVÁ
Institute for Toxicology and Forensic Chemistry, Charles University and University General Hospital, Prague, Czech Republic
Streszczenie
The aim of the study was to carry out a the laboratory diagnosis of fetal drug exposure. We focused on the analysis of meconium, as a specimen widely accepted for this purpose. In the preliminary study on meconium samples spiked with methamphetamine or morphine we tested the conditions for homogenization and isolation. Emit was used as a screening method and two dimensional HPTLC, GC/ECD, NPD and exceptionally also GC/MS as confirmation methods. The limit of detection was 0.5 mg/g meconium for both drugs. 39 meconium samples from babies newly born to mothers suspected of drug abuse were analyzed for methamphetamine and/or morphine. 18 of them were positive. In 29 cases both meconium and urine were available. The results and their possible interpretation are discussed.
Słowa kluczowe
Meconium; Methamphetamine; Opiates.