Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 243-249
FATAL INTOXICATION BY CIBENZOLINE (CIPRALAN®)
N. RICHARD, Marie H. GHYSEL, M. SAVART
Laboratoire de Police Scientifique, Lille, France
Streszczenie
We report here a fatal case of intoxication by an antiarrythmic drug, cibenzoline, concerning a woman who was found dead 3 hours after ingesting an unknown amount of Cipralan(r) tablets. Toxicological screening is performed on blood, gastric content and bile after extraction using Toxi-Tube(r)A. Cibenzoline is identified by gas chromatography with mass spectrometry detection (GC/MS) and high performance liquid chromatography with diode array detection (HPLC-DAD). Quantitation of cibenzoline is performed by HPLC at 220 nm after liquid extraction at pH 9 by chloroform/isopropanol (9:1, v/v) using di-p-methylcibenzoline as internal standard. Column used is a C18 Nova Pack Waters, mobile phase is acetonitrile, methanol and ammonium acetate at 7,5 g/l (30:30:40, v/v/v). Flow rate is 0.7 ml/min. Blood alcohol concentration is 2.9 g/l. Mesured concentrations of cibenzoline are 22.8 mg/l in blood, 31.4 mg/l in gastric content and 76.1 mg/l in bile.
Słowa kluczowe
Cibenzoline; Antiarrythmic drug; Post-mortem material.