Problems of Forensic Sciences 2000 Vol. 42 (XLII) 36-40
QUANTITATIVE DETERMINATION OF PARAQUAT BY HPLC-DAD FOLLOWING CHEMICAL REDUCTION WITH SODIUM BOROHYDRIDE IN A FATAL INTOXICATION
Katrien M. ARYS1, Jan F. VAN BOCXLAER1, Karine CLAUWAERT1, Willy LAMBERT1, Michel PIETTE2, Carlos VAN PETEGHEM1, Andreas DE LEENHEER1
1Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, University of Ghent, Ghent, Belgium
2Laboratory of Legal Medicine, Faculty of Medicine, University of Ghent, Ghent, Belgium
Streszczenie
This report describes the analytical findings in a fatal case of massive paraquat ingestion. The objective of our work was to establish a reliable method for the analysis of the ionized paraquat using HPLC in combination with diode array detection following chemical reduction with sodium borohydride.
Słowa kluczowe
Paraquat intoxication; Sodium borohydride reduction; HPLC-DAD.