Problems of Forensic Sciences 2000 Vol. 42 (XLII) 202-208
SCREENING FOR DRUGS IN SERUM AND URINE BY LC/ESI/CID-MS AND MS/MS WITH LIBRARY SEARCHING
Wolfgang WEINMANN1, Natalie LEHMANN1, Michaela RENZ1, Alexander WIEDEMANN1, Michal SVOBODA2
1Institute of Legal Medicine, University of Freiburg, Freiburg, Germany
2Perkin-Elmer Biosystems, Langen, Germany
Streszczenie
A mass spectra library using in-source collision induced dissociation (ESI/CID) as well as a MS/MS library with product ion spectra of ca. 500 drugs have been developed with a triple-quadrupole ionspray mass spectrometer. For the ESI/CID MS library single quadrupole mode and for the MS/MS library triple-quadrupole mode were used. The libraries have been used for general-unknown screening and for identification of drugs and metabolites in serum and urine.
Słowa kluczowe
LC/MS; Mass spectra library; MS/MS.