Problems of Forensic Sciences 2000 Vol. 43 (XLIII) 105-111
THREE CASES OF THINNER-SNIFFING AND ESTIMATING THE FATAL CONCENTRATION OF TOLUENE BY TOXICOKINETICS
Tatsuya HOBARA, Masayuki OKUDA, Masayuki GOTOH, Kouichi OKI, Hiroyuki SEGAWA, Ichiro KUNITSUGU
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan
Streszczenie
To determine the potentially lethal level of thinner concentration in the air, we measured the concentration of toluene in the blood and other media of three patients who suffered sever acute thinner intoxication between 4 January 1996 and 21 April 1977 in Ube city. The concentration of toluene in blood were 30.2 mg/l in dead patient, and 13.7 mg/l and 17.5 mg/l in recovered patients, respectively. By extrapolation from the results of our previous toxicokinetic reseach on toluene poisoning in anesthetized dogs, the fatal concentration of toluene was estimated to be approximately 1800 to 2000 ppm over a one-hour exposure.
Słowa kluczowe
Toluene; Toxicokinetics; Hippuric acid.