Problems of Forensic Sciences 2005 Vol. 63 (LXIII) 235-240
APPLICATION OF LIQUID CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY TO DETERMINATION OF BENCYCLANE IN BIOLOGICAL SAMPLES
Przemysław PIOTROWSKI, Marzena SYKUTERA, Ewa PUFAL, Karol ŚLIWKA
Chair and Department of Forensic Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz
Streszczenie
This paper presents a method of determination of bencyclane by liquid chromatography coupled with mass spectrometry (LC-MS) in biological samples. This developed method was used to determine the concentration of bencyclane in a biological specimen collected during autopsy from the body of young female who had committed suicide by ingestion of an unknown quantity of Halidor®. As a result of the performed experiment, the following concentrations of bencyclane were determined: blood 3.8 µg/ml, liver 2.8 µg/g, kidney 3.8 µg/g, brain 4.1 µg/g. This method allows qualitative and quantitative analysis of bencyclane in biological samples and thus may be routinely used in forensic toxicology.
Słowa kluczowe
Bencyclane; Biological samples; LC-MS.