Problems of Forensic Sciences 2007 Vol. 70 (LXX) 225-235
IDENTIFICATION OF N-DESMETHYLSIBUTRAMINE AS A NEW INGREDIENT IN CHINESE HERBAL DIETARY SUPPLEMENTS
Dariusz BŁACHUT1, Agnieszka SIWIŃSKA-ZIÓŁKOWSKA2, Bogdan SZUKALSKI3, Krystyna WOJTASIEWICZ4, Zbigniew CZARNOCKI4, Agnieszka KOBYŁECKA2, Marta BYKAS-STRĘKOWSKA1
1Forensic Examination Bureau, The Internal Security Agency, Warsaw, Poland
2Department of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland
3Institute of Psychiatry and Neurology, Warsaw, Poland
4Faculty of Chemistry, University of Warsaw, Warsaw, Poland
Streszczenie
Recently a significant modification in the composition of a preparation named LiDa has been observed. GC-MS analysis of capsules content performed at the Forensic Examination Bureau, Internal Security Agency indicates the presence of an individual component similar to sibutramine. After isolating the component by column chromatography and performing a series of examinations using infrared spectroscopy (IR) as well as proton (1HNMR) and carbon (13C NMR) magnetic resonance, the unknown component was identified as N-desmethylsibutramine hydrochloride. The correctness of the structure determination was confirmed by synthesis of the reference material.
Słowa kluczowe
Sibutramine; N-desmethylsibutramine; LiDA; Meizitang.