Problems of Forensic Sciences 2010 Vol. 83 (LXXXIII) 288-297
DETERMINATION OF CITALOPRAM AND ITS ENANTIOMERS BY MEANS OF CHROMATOGRAPHIC TECHNIQUES
Jagoda MAJCHERCZYK 1, Maksymilian KULZA 2
1Department of Analytical Chemistry, Jagiellonian University, Kraków, Poland
2Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Poznań, Poland
Streszczenie
This paper presents a review of the most popular chromatographic techniques which are used for determination of citalopram (CIT) and its metabolites in biological specimens. These techniques have been divided according to their enantioselective properties. Examples of their applications in routine analysis of clinical and post-mortem material are presented as well. This work also covers a description of chemical and pharmacological properties of citalopram.
Słowa kluczowe
Citalopram; Enantiomers; Selective serotonin reuptake inhibitors.